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Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice

Direct communication between arteries and veins without intervening capillary beds is the primary pathology of arteriovenous malformations (AVMs). Although Notch signaling is implicated in embryonic arteriovenous (AV) differentiation, its function in the adult mammalian vasculature has not been esta...

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Main Authors: Carlson, Timothy R., Yan, Yibing, Wu, Xiaoqing, Lam, Michael T., Tang, Gale L., Beverly, Levi J., Messina, Louis M., Capobianco, Anthony J., Werb, Zena, Wang, Rong
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2005
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1175015/
https://ncbi.nlm.nih.gov/pubmed/15994223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504391102
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