Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels

Arteriovenous (AV) malformation (AVM) is a devastating condition characterized by focal lesions of enlarged, tangled vessels that shunt blood from arteries directly to veins. AVMs can form anywhere in the body and can cause debilitating ischemia and life-threatening hemorrhagic stroke. The mechanism...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Murphy, Patrick A., Kim, Tyson N., Huang, Lawrence, Nielsen, Corinne M., Lawton, Michael T., Adams, Ralf H., Schaffer, Chris B., Wang, Rong A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2014
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273347/
https://ncbi.nlm.nih.gov/pubmed/25468970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415316111
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