Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels

Arteriovenous (AV) malformation (AVM) is a devastating condition characterized by focal lesions of enlarged, tangled vessels that shunt blood from arteries directly to veins. AVMs can form anywhere in the body and can cause debilitating ischemia and life-threatening hemorrhagic stroke. The mechanism...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Murphy, Patrick A., Kim, Tyson N., Huang, Lawrence, Nielsen, Corinne M., Lawton, Michael T., Adams, Ralf H., Schaffer, Chris B., Wang, Rong A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273347/
https://ncbi.nlm.nih.gov/pubmed/25468970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415316111
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