Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels

Arteriovenous (AV) malformation (AVM) is a devastating condition characterized by focal lesions of enlarged, tangled vessels that shunt blood from arteries directly to veins. AVMs can form anywhere in the body and can cause debilitating ischemia and life-threatening hemorrhagic stroke. The mechanism...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Murphy, Patrick A., Kim, Tyson N., Huang, Lawrence, Nielsen, Corinne M., Lawton, Michael T., Adams, Ralf H., Schaffer, Chris B., Wang, Rong A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4273347/
https://ncbi.nlm.nih.gov/pubmed/25468970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415316111
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