Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks

Homologous recombination (HR) deficient cells are sensitive to methyl methanesulfonate (MMS). HR is usually involved in the repair of DNA double-strand breaks (DSBs) in Saccharomyces cerevisiae implying that MMS somehow induces DSBs in vivo. Indeed there is evidence, based on pulsed-field gel electr...

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Hauptverfasser: Lundin, Cecilia, North, Matthew, Erixon, Klaus, Walters, Kevin, Jenssen, Dag, Goldman, Alastair S. H., Helleday, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1174933/
https://ncbi.nlm.nih.gov/pubmed/16009812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki681
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