Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN(+/-) mice by the p85 regulatory subunits of phosphoinositide 3-kinase

Mice with heterozygous deletion of the PTEN tumor suppressor gene develop a range of epithelial neoplasia as well as lymphoid hyperplasia. Previous studies suggest that PTEN suppresses tumor formation by acting as a phosphoinositide phosphatase to limit signaling by phosphoinositide 3-kinase (PI3K)....

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Main Authors: Luo, Ji, Sobkiw, Cassandra L., Logsdon, Nicole M., Watt, John M., Signoretti, Sabina, O'Connell, Fionnuala, Shin, Eyoung, Shim, Youngju, Pao, Lily, Neel, Benjamin G., DePinho, Ronald A., Loda, Massimo, Cantley, Lewis C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2005
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1174923/
https://ncbi.nlm.nih.gov/pubmed/16006513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504378102
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