The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages

Biglycan, a small leucine-rich proteoglycan, is a ubiquitous ECM component; however, its biological role has not been elucidated in detail. Here we show that biglycan acts in macrophages as an endogenous ligand of TLR4 and TLR2, which mediate innate immunity, leading to rapid activation of p38, ERK,...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Schaefer, Liliana, Babelova, Andrea, Kiss, Eva, Hausser, Heinz-J., Baliova, Martina, Krzyzankova, Miroslava, Marsche, Gunther, Young, Marian F., Mihalik, Daniel, Götte, Martin, Malle, Ernst, Schaefer, Roland M., Gröne, Hermann-Josef
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Clinical Investigation 2005
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC1174916/
https://ncbi.nlm.nih.gov/pubmed/16025156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI23755
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