Decorin-Mediated Regulation of Fibrillin-1 in the Kidney Involves the Insulin-Like Growth Factor-I Receptor and Mammalian Target of Rapamycin

Decorin, a small leucine-rich proteoglycan, affects the synthesis of the elastic fiber component fibrillin-1 in the kidney via hitherto unknown mechanisms. Here, we show that decorin binds to and induces phosphorylation of insulin-like growth factor-I (IGF-I) receptor in renal fibroblasts. Inhibitio...

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Detalhes bibliográficos
Main Authors: Schaefer, Liliana, Tsalastra, Wasiliki, Babelova, Andrea, Baliova, Martina, Minnerup, Jens, Sorokin, Lydia, Gröne, Hermann-Josef, Reinhardt, Dieter P., Pfeilschifter, Josef, Iozzo, Renato V., Schaefer, Roland M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2007
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1762680/
https://ncbi.nlm.nih.gov/pubmed/17200203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060497
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