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Decorin deficiency in diabetic mice: Aggravation of nephropathy due to overexpression of profibrotic factors, enhanced apoptosis and mononuclear cell infiltration

Although deficiency of the small leucine-rich proteoglycan decorin aggravates diabetic nephropathy in mice, the precise mechanisms of action are not fully understood. In the present study we used decorin-deficient mice (Dcn(−/−)) to further elucidate the molecular mechanisms involved in the protecti...

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Publicat a:J Physiol Pharmacol
Autors principals: Merline, Rosetta, Lazaroski, Sandra, Babelova, Andrea, Tsalastra-Greul, Wasiliki, Pfeilschifter, Josef, Schlüter, Klaus-Dieter, Günther, Andreas, Iozzo, Renato V., Schaefer, Roland M., Schaefer, Liliana
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6714047/
https://ncbi.nlm.nih.gov/pubmed/20083846
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