The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis

CXCL13 is a key B cell chemoattractant and marker of disease activity in patients with SLE; however, the mechanism of its induction has not been identified yet. Here, we have shown that the proteoglycan biglycan triggers CXCL13 expression via TLR2/4 in macrophages and dendritic cells. In vivo, level...

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Detalhes bibliográficos
Main Authors: Moreth, Kristin, Brodbeck, Rebekka, Babelova, Andrea, Gretz, Norbert, Spieker, Tilmann, Zeng-Brouwers, Jinyang, Pfeilschifter, Josef, Young, Marian F., Schaefer, Roland M., Schaefer, Liliana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993585/
https://ncbi.nlm.nih.gov/pubmed/21084753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42213
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