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Protein folding mediated by solvation: Water expulsion and formation of the hydrophobic core occur after the structural collapse

The interplay between structure-search of the native structure and desolvation in protein folding has been explored using a minimalist model. These results support a folding mechanism where most of the structural formation of the protein is achieved before water is expelled from the hydrophobic core...

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Bibliografski detalji
Glavni autori: Cheung, Margaret S., García, Angel E., Onuchic, José N.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2002
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC117366/
https://ncbi.nlm.nih.gov/pubmed/11805324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022387699
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