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Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides

Classical ligands bind to the extracellular surface of their cognate receptors and activate signaling pathways without crossing the plasma membrane barrier. We selectively targeted the intracellular receptor–G protein interface by using cell-penetrating membrane-tethered peptides. Attachment of a pa...

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Autors principals: Covic, Lidija, Gresser, Amy L., Talavera, Joyce, Swift, Steven, Kuliopulos, Athan
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC117359/
https://ncbi.nlm.nih.gov/pubmed/11805322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022460899
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