A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy.

A mutation equivalent to P102L in the human PrP gene, associated with Gerstmann-Straussler syndrome (GSS), has been introduced into the murine PrP gene by gene targeting. Mice homozygous for this mutation (101LL) showed no spontaneous transmissible spongiform encephalopathy (TSE) disease, but had in...

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Main Authors: Manson, J C, Jamieson, E, Baybutt, H, Tuzi, N L, Barron, R, McConnell, I, Somerville, R, Ironside, J, Will, R, Sy, M S, Melton, D W, Hope, J, Bostock, C
Formato: Artigo
Idioma:Inglês
Publicado: 1999
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171748/
https://ncbi.nlm.nih.gov/pubmed/10581259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.23.6855
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