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Changing a single amino acid in the N-terminus of murine PrP alters TSE incubation time across three species barriers
The PrP gene of the host exerts a major influence over the outcome of transmissible spongiform encephalopathy (TSE) disease, but the mechanism by which this is achieved is not understood. We have introduced a specific mutation into the endogenous murine PrP gene using gene targeting to produce trans...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125625/ https://ncbi.nlm.nih.gov/pubmed/11566872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.18.5070 |
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