Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor.

In Rat-1 fibroblasts epidermal growth factor (EGF), but not platelet-derived growth factor (PDGF) stimulates the activity of the c-Jun N-terminal kinase (JNK). Moreover, PDGF induced suppression of EGF-mediated JNK activation, apparently through protein kinase C (PKC) activation. Further analysis re...

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Detalhes bibliográficos
Main Authors: Bagowski, C P, Stein-Gerlach, M, Choidas, A, Ullrich, A
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171625/
https://ncbi.nlm.nih.gov/pubmed/10523301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.20.5567
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