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Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.
Ectopic expression of Myc induces Cdk2 kinase activity in quiescent cells and antagonizes association of p27(kip1) with Cdk2. The target gene(s) by which Myc mediates this effect is largely unknown. We now show that p27 is rapidly and transiently sequestered by cyclin D2-Cdk4 complexes upon activati...
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
1999
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171602/ https://ncbi.nlm.nih.gov/pubmed/10508165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.19.5321 |
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