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Division of labor--sequential ATP hydrolysis drives assembly of a DNA polymerase sliding clamp around DNA.
The beta sliding clamp encircles DNA and enables processive replication of the Escherichia coli genome by DNA polymerase III holoenzyme. The clamp loader, gamma complex, assembles beta around DNA in an ATP-fueled reaction. Previous studies have shown that gamma complex opens the beta ring and also i...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171583/ https://ncbi.nlm.nih.gov/pubmed/10487764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.18.5131 |
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