Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.

Wnt proteins transduce their signals through dishevelled (Dvl) proteins to inhibit glycogen synthase kinase 3beta (GSK), leading to the accumulation of cytosolic beta-catenin and activation of TCF/LEF-1 transcription factors. To understand the mechanism by which Dvl acts through GSK to regulate LEF-...

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Main Authors: Li, L, Yuan, H, Weaver, C D, Mao, J, Farr, G H, Sussman, D J, Jonkers, J, Kimelman, D, Wu, D
Format: Artigo
Jezik:Inglês
Izdano: 1999
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171499/
https://ncbi.nlm.nih.gov/pubmed/10428961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.15.4233
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