Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription.

Axin promotes the phosphorylation of beta-catenin by GSK-3beta, leading to beta-catenin degradation. Wnt signals interfere with beta-catenin turnover, resulting in enhanced transcription of target genes through the increased formation of beta-catenin complexes containing TCF transcription factors. L...

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Detalhes bibliográficos
Main Authors: Smalley, M J, Sara, E, Paterson, H, Naylor, S, Cook, D, Jayatilake, H, Fryer, L G, Hutchinson, L, Fry, M J, Dale, T C
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171363/
https://ncbi.nlm.nih.gov/pubmed/10329628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.10.2823
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