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The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx.
The Pax3-FKHR fusion protein is present in alveolar rhabdomyosarcoma and results from the t(2;13) (q35;q14) chromosomal translocation. Its oncogenic activity is dependent on a combination of protein-DNA and protein-protein interactions mediated by the Pax3 homeodomain recognition helix. In this repo...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
1999
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171447/ https://ncbi.nlm.nih.gov/pubmed/10393185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.13.3702 |
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