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High Expression of the PAX3-FKHR Oncoprotein Is Required to Promote Tumorigenesis of Human Myoblasts

PAX3-FKHR is a fusion oncoprotein generated by the 2;13 chromosomal translocation in alveolar rhabdomyosarcoma (ARMS), a cancer associated with the skeletal muscle lineage. Previous studies determined that high-level PAX3-FKHR expression is a consistent feature in ARMS tumors. To investigate the rel...

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Bibliografiske detaljer
Main Authors: Xia, Shujuan J., Holder, Dara D., Pawel, Bruce R., Zhang, Chune, Barr, Frederic G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789624/
https://ncbi.nlm.nih.gov/pubmed/19893043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090192
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