Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae.

Functional cloning led to the isolation of a novel methotrexate (MTX) resistance gene in the protozoan parasite Leishmania. The gene corresponds to orfG, an open reading frame (ORF) of the LD1/CD1 genomic locus that is frequently amplified in several Leishmania stocks. A functional ORF G-green fluor...

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Main Authors: Kündig, C, Haimeur, A, Légaré, D, Papadopoulou, B, Ouellette, M
Formato: Artigo
Idioma:Inglês
Publicado: 1999
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171317/
https://ncbi.nlm.nih.gov/pubmed/10228149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.9.2342
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