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The internal workings of a DNA polymerase clamp-loading machine.
Replicative DNA polymerases are multiprotein machines that are tethered to DNA during chain extension by sliding clamp proteins. The clamps are designed to encircle DNA completely, and they are manipulated rapidly onto DNA by the ATP-dependent activity of a clamp loader. We outline the detailed mech...
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主要な著者: | , , , |
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フォーマット: | Artigo |
言語: | Inglês |
出版事項: |
1999
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171170/ https://ncbi.nlm.nih.gov/pubmed/9927437 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.3.771 |
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