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A Central Swivel Point in the RFC Clamp Loader Controls PCNA Opening and Loading on DNA
Replication Factor C (RFC) is a 5-subunit complex that loads PCNA clamps onto primer-template DNA (ptDNA) during replication. RFC subunits belong to the AAA+ superfamily, and their ATPase activity drives interactions between the clamp loader, clamp, and ptDNA, leading to topologically linked PCNA•pt...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3269524/ https://ncbi.nlm.nih.gov/pubmed/22197374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.017 |
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