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A Central Swivel Point in the RFC Clamp Loader Controls PCNA Opening and Loading on DNA

Replication Factor C (RFC) is a 5-subunit complex that loads PCNA clamps onto primer-template DNA (ptDNA) during replication. RFC subunits belong to the AAA+ superfamily, and their ATPase activity drives interactions between the clamp loader, clamp, and ptDNA, leading to topologically linked PCNA•pt...

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Autores principales: Sakato, Miho, O’Donnell, Mike, Hingorani, Manju M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269524/
https://ncbi.nlm.nih.gov/pubmed/22197374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.017
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