Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction.

SOCS-1 (suppressor of cytokine signaling-1) is a representative of a family of negative regulators of cytokine signaling (SOCS-1 to SOCS-7 and CIS) characterized by a highly conserved C-terminal SOCS box preceded by an SH2 domain. This study comprehensively examined the ability of several SOCS famil...

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Detalhes bibliográficos
Main Authors: Nicholson, S E, Willson, T A, Farley, A, Starr, R, Zhang, J G, Baca, M, Alexander, W S, Metcalf, D, Hilton, D J, Nicola, N A
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171132/
https://ncbi.nlm.nih.gov/pubmed/9889194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.2.375
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