Targeted disruption of SHIP leads to Steel factor-induced degranulation of mast cells.

To investigate the role of the src homology 2 (SH2)-containing inositol 5' phosphatase (SHIP) in growth factor-mediated signalling, we compared Steel factor (SF)-induced events in bone marrow-derived mast cells (BMMCs) from SHIP-/- and SHIP+/+ littermates. We found SF alone stimulated massive d...

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Hauptverfasser: Huber, M, Helgason, C D, Scheid, M P, Duronio, V, Humphries, R K, Krystal, G
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1998
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171077/
https://ncbi.nlm.nih.gov/pubmed/9857188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.24.7311
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