Binary specification of nonsense codons by splicing and cytoplasmic translation.

Premature translation termination codons resulting from nonsense or frameshift mutations are common causes of genetic disorders. Complications arising from the synthesis of C-terminally truncated polypeptides can be avoided by 'nonsense-mediated decay' of the mutant mRNAs. Premature termin...

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Bibliografische gegevens
Hoofdauteurs: Thermann, R, Neu-Yilik, G, Deters, A, Frede, U, Wehr, K, Hagemeier, C, Hentze, M W, Kulozik, A E
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1998
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170685/
https://ncbi.nlm.nih.gov/pubmed/9628884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.12.3484
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