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Crystal structure of the angiogenesis inhibitor endostatin at 1.5 A resolution.
A number of extracellular proteins contain cryptic inhibitors of angiogenesis. Endostatin is a 20 kDa C-terminal proteolytic fragment of collagen XVIII that potently inhibits endothelial cell proliferation and angiogenesis. Therapy of experimental cancer with endostatin leads to tumour dormancy and...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
European Molecular Biology Organization
1998
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170513/ https://ncbi.nlm.nih.gov/pubmed/9501087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.6.1656 |
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