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Structural basis and potential role of heparin/heparan sulfate binding to the angiogenesis inhibitor endostatin.
Recombinant mouse endostatin produced by mammalian cells was shown to bind to heparin with a K(d) of 0.3 microM, suggesting that this interaction may play a role in its anti-angiogenic activity. Alanine mutagenesis demonstrated that a major site of four clustered arginines (positions 155, 158, 184 a...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171687/ https://ncbi.nlm.nih.gov/pubmed/10562536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.22.6240 |
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