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Structural basis and potential role of heparin/heparan sulfate binding to the angiogenesis inhibitor endostatin.

Recombinant mouse endostatin produced by mammalian cells was shown to bind to heparin with a K(d) of 0.3 microM, suggesting that this interaction may play a role in its anti-angiogenic activity. Alanine mutagenesis demonstrated that a major site of four clustered arginines (positions 155, 158, 184 a...

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Bibliografische gegevens
Hoofdauteurs: Sasaki, T, Larsson, H, Kreuger, J, Salmivirta, M, Claesson-Welsh, L, Lindahl, U, Hohenester, E, Timpl, R
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1999
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171687/
https://ncbi.nlm.nih.gov/pubmed/10562536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.22.6240
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