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Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM-40/SPARC/osteonectin.

The extracellular calcium-binding domain (positions 138-286) of the matrix protein BM-40 possesses a binding epitope of moderate affinity for several collagen types. This epitope was predicted to reside in helix alphaA and to be partially masked by helix alphaC. Here we show that deletion of helix a...

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Autori principali: Sasaki, T, Hohenester, E, Göhring, W, Timpl, R
Natura: Artigo
Lingua:Inglês
Pubblicazione: European Molecular Biology Organization 1998
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170510/
https://ncbi.nlm.nih.gov/pubmed/9501084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.6.1625
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