Mapping of SPARC/BM-40/Osteonectin-binding Sites on Fibrillar Collagens

The 33-kDa matrix protein SPARC (BM-40, osteonectin) binds several collagen types with moderate affinity. The collagen-binding site resides in helix αA of the extracellular calcium-binding domain of SPARC and is partially masked by helix αC. Previously, we found that the removal of helix αC caused a...

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Main Authors: Giudici, Camilla, Raynal, Nicolas, Wiedemann, Hanna, Cabral, Wayne A., Marini, Joan C., Timpl, Rupert, Bächinger, Hans Peter, Farndale, Richard W., Sasaki, Takako, Tenni, Ruggero
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Glycobiology and Extracellular Matrices
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443679/
https://ncbi.nlm.nih.gov/pubmed/18487610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710001200
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