Converting blood coagulation factor IXa into factor Xa: dramatic increase in amidolytic activity identifies important active site determinants.

The coagulation factors IXa (fIXa) and Xa (fXa) share extensive structural and functional homology; both cleave natural substrates effectively only with a cofactor at a phospholipid surface. However, the amidolytic activity of fIXa is 10(4)-fold lower than that of fXa. To identify determinants of th...

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Detaylı Bibliyografya
Asıl Yazarlar: Hopfner, K P, Brandstetter, H, Karcher, A, Kopetzki, E, Huber, R, Engh, R A, Bode, W
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1997
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170267/
https://ncbi.nlm.nih.gov/pubmed/9362477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.22.6626
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