X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B.
Hereditary deficiency of factor IXa (fIXa), a key enzyme in blood coagulation, causes hemophilia B, a severe X chromosome-linked bleeding disorder afflicting 1 in 30,000 males; clinical studies have identified nearly 500 deleterious variants. The x-ray structure of porcine fIXa described here shows...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40889/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7568220/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.21.9796 |
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