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Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signaling.

Binding of macrophage colony stimulating factor (M-CSF) to its receptor (Fms) induces dimerization and activation of the tyrosine kinase domain of the receptor, resulting in autophosphorylation of cytoplasmic tyrosine residues used as docking sites for SH2-containing signaling proteins that relay gr...

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Detalhes bibliográficos
Main Authors: Bourette, R P, Myles, G M, Choi, J L, Rohrschneider, L R
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170219/
https://ncbi.nlm.nih.gov/pubmed/9312046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.19.5880
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