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Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.

In a cell-free system based on Xenopus egg extracts, Bcl-2 blocks apoptotic activity by preventing cytochrome c release from mitochondria. We now describe in detail the crucial role of cytochrome c in this system. The mitochondrial fraction, when incubated with cytosol, releases cytochrome c. Cytoch...

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Autors principals: Kluck, R M, Martin, S J, Hoffman, B M, Zhou, J S, Green, D R, Newmeyer, D D
Format: Artigo
Idioma:Inglês
Publicat: 1997
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170090/
https://ncbi.nlm.nih.gov/pubmed/9303308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.15.4639
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