Antistaphylococcal Effect Related to the Area under the Curve/MIC Ratio in an In Vitro Dynamic Model: Predicted Breakpoints versus Clinically Achievable Values for Seven Fluoroquinolones

Prediction of the relative efficacies of different fluoroquinolones is often based on the ratios of the clinically achievable area under the concentration-time curve (AUC) to the MIC, usually with incorporation of the MIC(50) or the MIC(90) and with the assumption of antibiotic-independent patterns...

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Detalhes bibliográficos
Main Authors: Firsov, Alexander A., Lubenko, Irene Y., Vostrov, Sergey N., Portnoy, Yury A., Zinner, Stephen H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168651/
https://ncbi.nlm.nih.gov/pubmed/15980331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.7.2642-2647.2005
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