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Antistaphylococcal Effect Related to the Area under the Curve/MIC Ratio in an In Vitro Dynamic Model: Predicted Breakpoints versus Clinically Achievable Values for Seven Fluoroquinolones

Prediction of the relative efficacies of different fluoroquinolones is often based on the ratios of the clinically achievable area under the concentration-time curve (AUC) to the MIC, usually with incorporation of the MIC(50) or the MIC(90) and with the assumption of antibiotic-independent patterns...

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Main Authors: Firsov, Alexander A., Lubenko, Irene Y., Vostrov, Sergey N., Portnoy, Yury A., Zinner, Stephen H.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168651/
https://ncbi.nlm.nih.gov/pubmed/15980331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.7.2642-2647.2005
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