Basal Activation of the P2X(7) ATP Receptor Elevates Mitochondrial Calcium and Potential, Increases Cellular ATP Levels, and Promotes Serum-independent Growth

P2X(7) is a bifunctional receptor (P2X(7)R) for extracellular ATP that, depending on the level of activation, forms a cation-selective channel or a large conductance nonselective pore. The P2X(7)R has a strong proapoptotic activity but can also support growth. Here, we describe the mechanism involve...

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Main Authors: Adinolfi, Elena, Callegari, Maria Giulia, Ferrari, Davide, Bolognesi, Chiara, Minelli, Mattia, Wieckowski, Mariusz R., Pinton, Paolo, Rizzuto, Rosario, Di Virgilio, Francesco
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2005
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1165409/
https://ncbi.nlm.nih.gov/pubmed/15901833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-11-1025
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