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Basal Activation of the P2X(7) ATP Receptor Elevates Mitochondrial Calcium and Potential, Increases Cellular ATP Levels, and Promotes Serum-independent Growth
P2X(7) is a bifunctional receptor (P2X(7)R) for extracellular ATP that, depending on the level of activation, forms a cation-selective channel or a large conductance nonselective pore. The P2X(7)R has a strong proapoptotic activity but can also support growth. Here, we describe the mechanism involve...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Cell Biology
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1165409/ https://ncbi.nlm.nih.gov/pubmed/15901833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-11-1025 |
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