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Sensitivity of Human Immunodeficiency Virus Type 1 to the Fusion Inhibitor T-20 Is Modulated by Coreceptor Specificity Defined by the V3 Loop of gp120

T-20 is a synthetic peptide that potently inhibits replication of human immunodeficiency virus type 1 by interfering with the transition of the transmembrane protein, gp41, to a fusion active state following interactions of the surface glycoprotein, gp120, with CD4 and coreceptor molecules displayed...

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Autors principals: Derdeyn, Cynthia A., Decker, Julie M., Sfakianos, Jeffrey N., Wu, Xiaoyun, O'Brien, William A., Ratner, Lee, Kappes, John C., Shaw, George M., Hunter, Eric
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC116346/
https://ncbi.nlm.nih.gov/pubmed/10954535
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