Clustered Charge-to-Alanine Mutagenesis of the Vaccinia Virus A20 Gene: Temperature-Sensitive Mutants Have a DNA-Minus Phenotype and Are Defective in the Production of Processive DNA Polymerase Activity

Although the vaccinia virus DNA polymerase is inherently distributive, a highly processive form of the enzyme exists within the cytoplasm of infected cells (W. F. McDonald, N. Klemperer, and P. Traktman, Virology 234:168–175, 1997). In the accompanying report we outline the purification of the 49-kD...

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Pubblicato in:	J Virol
Autori principali:	Punjabi, Almira, Boyle, Kathleen, DeMasi, Joseph, Grubisha, Olivera, Unger, Beth, Khanna, Marilyn, Traktman, Paula
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Replication
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC116127/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11711621/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.24.12308-12318.2001
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