Charged-to-Alanine Scanning Mutagenesis of the N-Terminal Half of Adeno-Associated Virus Type 2 Rep78 Protein

The adeno-associated virus (AAV) Rep78 and Rep68 proteins are required for site-specific integration of the AAV genome into the AAVS1 locus (19q13.3-qter) as well as for viral DNA replication. Rep78 and Rep68 bind to the GAGC motif on the inverted terminal repeat (ITR) and cut at the trs (terminal r...

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Bibliographische Detailangaben
Hauptverfasser: Urabe, Masashi, Hasumi, Yoko, Kume, Akihiro, Surosky, Richard T., Kurtzman, Gary J., Tobita, Kiyotake, Ozawa, Keiya
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1999
Schlagworte:
Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC104024/
https://ncbi.nlm.nih.gov/pubmed/10074114
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