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Charged-to-Alanine Scanning Mutagenesis of the N-Terminal Half of Adeno-Associated Virus Type 2 Rep78 Protein

The adeno-associated virus (AAV) Rep78 and Rep68 proteins are required for site-specific integration of the AAV genome into the AAVS1 locus (19q13.3-qter) as well as for viral DNA replication. Rep78 and Rep68 bind to the GAGC motif on the inverted terminal repeat (ITR) and cut at the trs (terminal r...

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Publicado no:J Virol
Principais autores: Urabe, Masashi, Hasumi, Yoko, Kume, Akihiro, Surosky, Richard T., Kurtzman, Gary J., Tobita, Kiyotake, Ozawa, Keiya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1999
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104024/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10074114/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.4.2682-2693.1999
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