Transcription-Dependent Nuclear-Cytoplasmic Trafficking Is Required for the Function of the von Hippel-Lindau Tumor Suppressor Protein

Mutation of the von Hippel-Lindau tumor suppressor gene (vhl) causes the von Hippel-Lindau cancer syndrome as well as sporadic renal clear cell carcinoma. To pursue our study of the intracellular localization of VHL protein in relation to its function, we fused VHL to the green fluorescent protein (...

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Bibliographic Details
Main Authors: Lee, Stephen, Neumann, Markus, Stearman, Robert, Stauber, Roland, Pause, Arnim, Pavlakis, George N., Klausner, Richard D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC116077/
https://ncbi.nlm.nih.gov/pubmed/9891082
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