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Herpes Simplex Virus Type 1 Blocks the Apoptotic Host Cell Defense Mechanisms That Target Bcl-2 and Manipulates Activation of p38 Mitogen-Activated Protein Kinase To Improve Viral Replication

Wild-type (wt) herpes simplex virus type 1 (HSV-1) suppresses cell death. We investigated the apoptotic pathways triggered during infection with mutant viruses tsk and 27lacZ (which lack functional ICP4 and ICP27 viral proteins, respectively) and examined the mechanisms used by wt HSV-1 to protect a...

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Udgivet i:J Virol
Principais autores: Zachos, George, Koffa, Margy, Preston, Chris M., Clements, J. Barklie, Conner, Joe
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC115896/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11222695/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.6.2710-2728.2001
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