Herpes Simplex Virus Type 1 Blocks the Apoptotic Host Cell Defense Mechanisms That Target Bcl-2 and Manipulates Activation of p38 Mitogen-Activated Protein Kinase To Improve Viral Replication

Wild-type (wt) herpes simplex virus type 1 (HSV-1) suppresses cell death. We investigated the apoptotic pathways triggered during infection with mutant viruses tsk and 27lacZ (which lack functional ICP4 and ICP27 viral proteins, respectively) and examined the mechanisms used by wt HSV-1 to protect a...

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Bibliografiska uppgifter
Huvudupphovsmän: Zachos, George, Koffa, Margy, Preston, Chris M., Clements, J. Barklie, Conner, Joe
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2001
Ämnen:
Virus-Cell Interactions
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC115896/
https://ncbi.nlm.nih.gov/pubmed/11222695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.6.2710-2728.2001
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