Herpes Simplex Virus Type 1 Blocks the Apoptotic Host Cell Defense Mechanisms That Target Bcl-2 and Manipulates Activation of p38 Mitogen-Activated Protein Kinase To Improve Viral Replication

Wild-type (wt) herpes simplex virus type 1 (HSV-1) suppresses cell death. We investigated the apoptotic pathways triggered during infection with mutant viruses tsk and 27lacZ (which lack functional ICP4 and ICP27 viral proteins, respectively) and examined the mechanisms used by wt HSV-1 to protect a...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Zachos, George, Koffa, Margy, Preston, Chris M., Clements, J. Barklie, Conner, Joe
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC115896/
https://ncbi.nlm.nih.gov/pubmed/11222695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.6.2710-2728.2001
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares