Human thiopurine S-methyltransferase pharmacogenetics: Variant allozyme misfolding and aggresome formation

Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs. TPMT genetic polymorphisms represent a striking example of the potential clinical value of pharmacogenetics. Subjects homozygous for TPMT(*)3A, the most common variant allele for low activity, an allele that encod...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Wang, Liewei, Nguyen, Tien V., McLaughlin, Richard W., Sikkink, Laura A., Ramirez-Alvarado, Marina, Weinshilboum, Richard M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2005
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1153717/
https://ncbi.nlm.nih.gov/pubmed/15967990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502352102
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki