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Human thiopurine S-methyltransferase pharmacogenetics: Variant allozyme misfolding and aggresome formation
Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs. TPMT genetic polymorphisms represent a striking example of the potential clinical value of pharmacogenetics. Subjects homozygous for TPMT(*)3A, the most common variant allele for low activity, an allele that encod...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1153717/ https://ncbi.nlm.nih.gov/pubmed/15967990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502352102 |
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