High affinity nucleic acid aptamers for streptavidin incorporated into bi-specific capture ligands

We have isolated 2′-Fluoro-substituted RNA aptamers that bind to streptavidin (SA) with an affinity around 7 ± 1.8 nM, comparable with that of recently described peptide aptamers. Binding to SA was not prevented by prior saturation with biotin, enabling nucleic acid aptamers to form useful ternary c...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Tahiri-Alaoui, Abdessamad, Frigotto, Laura, Manville, Nick, Ibrahim, Jamal, Romby, Pascale, James, William
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2002
Soggetti:	NAR Methods Online
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC115299/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12000850/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/30.10.e45
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