Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma

We have shown that the proteasome inhibitor bortezomib (formerly known as PS-341) triggers significant antitumor activity in multiple myeloma (MM) in both preclinical models and patients with relapsed refractory disease. Recent studies have shown that unfolded and misfolded ubiquitinated proteins ar...

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Autori principali: Hideshima, Teru, Bradner, James E., Wong, Jason, Chauhan, Dharminder, Richardson, Paul, Schreiber, Stuart L., Anderson, Kenneth C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1150844/
https://ncbi.nlm.nih.gov/pubmed/15937109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503221102
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